Invention Grant
- Patent Title: Oligonucleotide complexes for use in RNA editing
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Application No.: US16479101Application Date: 2018-01-18
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Publication No.: US11274300B2Publication Date: 2022-03-15
- Inventor: Antti Aalto , Janne Juha Turunen
- Applicant: ProQR Therapeutics II B.V.
- Applicant Address: NL Leiden
- Assignee: ProQR Therapeutics II B.V.
- Current Assignee: ProQR Therapeutics II B.V.
- Current Assignee Address: NL Leiden
- Agency: Goodwin Procter LLP
- Priority: GB1700939 20170119,GB1707511 20170510
- International Application: PCT/EP2018/051202 WO 20180118
- International Announcement: WO2018/134301 WO 20180726
- Main IPC: C12N15/11
- IPC: C12N15/11

Abstract:
The invention relates to double stranded oligonucleotide complexes comprising an antisense oligonucleotide (AON) and a complementary sense oligonucleotide (SON), for use in the deamination of a target adenosine in a sense target RNA sequence in a cell by an ADAR enzyme, wherein at least the nucleotide in the AON that is directly opposite the target adenosine in the target RNA sequence does not have a 2′-O-alkyl modification and the SON comprises nucleotides that are at least complementary to all nucleotides in the AON that do not have a 2′-O-alkyl modification. The invention further relates to methods of RNA editing using the AON/SON complexes of the invention.
Public/Granted literature
- US20190352641A1 OLIGONUCLEOTIDE COMPLEXES FOR USE IN RNA EDITING Public/Granted day:2019-11-21
Information query
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