A heating, ventilating, and air conditioning (HVAC) system includes a refrigerant loop having a compressor, where the compressor is configured to circulate a refrigerant through the refrigerant loop, a first heat exchanger disposed along the refrigerant loop, where the first heat exchanger is configured to place the refrigerant in a first heat exchange relationship with a working fluid, and an air handling unit having a second heat exchanger, where the second heat exchanger is configured to place the working fluid in a second heat exchange relationship with an airflow, and where the air handling unit is isolated from the first heat exchanger to reduce or eliminate mixing of refrigerant with the airflow.