There is provided an information processing system, an information processing method, and a program capable of changing a process to be executed in response to a recognition result of an inclination of a hand with respect to an object. The information processing system includes: an acquisition unit configured to acquire a recognition result of an inclination of a hand with respect to an object when it is recognized that the hand is touching the object; and a change unit configured to change a value of a parameter related to a process to be executed on the basis of the recognition result.