An AI routing framework for a multi-domain chatbot is provided. According to one set of embodiments, a computer system implementing the AI routing framework can receive a user query/request submitted to the multi-domain chatbot, determine an input statement corresponding to the user query/request, and calculate an embedding of the input statement reflecting the input statement's semantic content. The computer system can further identify, from among a plurality of statement embeddings maintained in a repository, a statement embedding that most closely matches the embedding of the input statement, and determine a domain associated with the identified statement embedding in the repository. The computer system can then forward the input statement to a handler of a back-end software system configured to process user queries/requests belonging to the determined domain.