A calculation method using pixel-channel shuffle convolutional neural network is provided. In the method, an operating system receives original input data. The original input data is pre-processed by a pixel shuffle process to be separated into multiple groups in order to minimize dimension of the data. The multiple groups of data are then processed by a channel shuffle process so as to form multiple groups of new input data selected for convolution operation. The unselected data are abandoned. Therefore, the dimension of the input data can be much effectively minimized. A multiplier-accumulator of the operating system is used to execute convolution operation using a convolution kernel and the multiple new groups of input data. Multiple output data are then produced.