Fuel bundles for a nuclear reactor are disclosed, and in some embodiments include a first fuel element including thorium dioxide; a second fuel element including uranium having a first fissile content; and a third fuel element including uranium having a second fissile content different from the first fissile content. Nuclear reactors using such fuel bundles are also disclosed, including pressurized heavy water nuclear reactors. The uranium having the different fissile contents can include combinations of natural uranium, depleted uranium, recycled uranium, slightly enriched uranium, and low enriched uranium.