Invention Grant
- Patent Title: Use of stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
-
Application No.: US16125702Application Date: 2018-09-08
-
Publication No.: US11278574B2Publication Date: 2022-03-22
- Inventor: Irina Kerkis , Cristiane Valverde Wenceslau
- Applicant: AVITA INTERNATIONAL LTD. , FUNDAçÃO BUTANTAN
- Applicant Address: VG Tortola; BR São Paulo, SP
- Assignee: AVITA INTERNATIONAL LTD.,FUNDAçÃO BUTANTAN
- Current Assignee: AVITA INTERNATIONAL LTD.,FUNDAçÃO BUTANTAN
- Current Assignee Address: VG Tortola; BR São Paulo, SP
- Agency: Booth Udall Fuller, PLC
- Agent Rodney J. Fuller
- Main IPC: C12N5/0775
- IPC: C12N5/0775 ; A61K35/32 ; A61P25/28 ; A61K9/00
Abstract:
The invention provides pharmaceutical compositions comprising human immature dental pulp stem cells (hIDPSCs) wherein the hIDPSCs express CD44 and CD13. The invention also provides methods of treating a neurological disease or condition comprising systemically administering to a subject a pharmaceutical composition comprising hIDPSCs wherein the hIDPSCs express CD44 and CD13. For example, for treating neurological diseases or conditions including supporting the neuro-protective mechanism in subjects diagnosed with early HD or repairing lost DA neurons in subjects diagnosed with PD.
Public/Granted literature
Information query
IPC分类:
