A folding knife can include a handle, a pivot mechanism, a blade retention member, and a replaceable blade. The pivot mechanism has a pivot element and an actuation member. The pivot element extends from one side of the handle. The actuation member is coupled to another side of the handle and is selectively movable without use of a tool to lock/unlock the side portions of the handle relative to each other. A proximal portion of the blade is releasably secured to the blade retention member, and a distal portion of the blade extends beyond the blade retention member. The blade retention member is pivotable relative to the handle between an open configuration in which a cutting edge portion of the blade is exposed from the handle and a closed configuration in which the cutting edge portion of the blade is concealed by the handle.