![Crystalline solid forms of salts of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use](/docs/US/2022-03-22/US11279675B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline solid forms of salts of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use
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Application No.: US16617352Application Date: 2018-05-26
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Publication No.: US11279675B2Publication Date: 2022-03-22
- Inventor: Khalid Shah
- Applicant: Exelixis, Inc.
- Applicant Address: US CA Alameda
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA Alameda
- Agency: Honigman LLP
- Agent Heidi M. Berven; Li Gao
- International Application: PCT/US2018/034784 WO 20180526
- International Announcement: WO2018/218233 WO 20181129
- Main IPC: C07D215/22
- IPC: C07D215/22
![Crystalline solid forms of salts of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use](/abs-image/US/2022/03/22/US11279675B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to novel crystalline solid forms of salts of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly renal cell carcinoma (RCC) and medullary thyroid cancer (MTC).
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