Invention Grant
- Patent Title: Crystalline of compound as c-Met kinase inhibitor and preparation method therefor and use thereof
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Application No.: US16977054Application Date: 2019-03-01
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Publication No.: US11279676B2Publication Date: 2022-03-22
- Inventor: Feng Gong , Ticong Huang , Haishan Zang , Shibo Zhang , Rui Zhao , Fei Liu
- Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. , ADVENCHEN LABORATORIES NANJING LTD.
- Applicant Address: CN Jiangsu; CN Jiangsu
- Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.,ADVENCHEN LABORATORIES NANJING LTD.
- Current Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.,ADVENCHEN LABORATORIES NANJING LTD.
- Current Assignee Address: CN Jiangsu; CN Jiangsu
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: CN201810174767.4 20180302
- International Application: PCT/CN2019/076683 WO 20190301
- International Announcement: WO2019/166012 WO 20190906
- Main IPC: C07D215/22
- IPC: C07D215/22

Abstract:
The present application falls within the field of medicinal chemistry, relates to the crystalline of a compound as a c-Met kinase inhibitor, and specifically relates to the crystalline of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystalline for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystalline of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
Public/Granted literature
- US20210047272A1 CRYSTALLINE OF COMPOUND AS C-MET KINASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF Public/Granted day:2021-02-18
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