Invention Grant
- Patent Title: Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer
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Application No.: US16689856Application Date: 2019-11-20
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Publication No.: US11279698B2Publication Date: 2022-03-22
- Inventor: John W. Babich , Justin Wilson , Nikki Thiele , James Kelly , Shashikanth Ponnala
- Applicant: Cornell University
- Applicant Address: US NY Ithaca
- Assignee: Cornell University
- Current Assignee: Cornell University
- Current Assignee Address: US NY Ithaca
- Agency: Foley & Lardner LLP
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K51/04 ; C07B59/00 ; A61K45/06

Abstract:
The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.
Public/Granted literature
- US20200157087A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER Public/Granted day:2020-05-21
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