Invention Grant
- Patent Title: Cyclodextrin dimers, compositions thereof, and uses thereof
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Application No.: US16733945Application Date: 2020-01-03
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Publication No.: US11279774B2Publication Date: 2022-03-22
- Inventor: Matthew S. O'Connor , Milo Malanga , Michael Kope , Christina A. T. M. B. Tom , Amelia M. Anderson
- Applicant: UNDERDOG PHARMACEUTICALS, INC.
- Applicant Address: US CA Mountain View
- Assignee: UNDERDOG PHARMACEUTICALS, INC.
- Current Assignee: UNDERDOG PHARMACEUTICALS, INC.
- Current Assignee Address: US CA Mountain View
- Agency: Baker, Donelson, Bearman, Caldwell & Berkowitz PC
- Agent Kenneth J. Kalafus
- Main IPC: C08B37/16
- IPC: C08B37/16 ; A61K31/724
Abstract:
A new class of synthetic cyclodextrin dimers is described. Exemplary cyclodextrin dimers can treat atherosclerotic plaques by targeting various forms cholesterol both intracellularly and extracellularly. Also provided are methods of depleting atherosclerotic plaques of cholesterol, cholesterol esters, 7-ketocholesterol and 7-ketocholesterol esters by treatment with such cyclodextrins. Further described are subclasses of dimers that have high specificity for 7-ketocholesterol.
Public/Granted literature
- US20200216576A1 CYCLODEXTRIN DIMERS, COMPOSITIONS THEREOF, AND USES THEREOF Public/Granted day:2020-07-09
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