Embodiments of the disclosure provide systems and methods for audio signal processing. An exemplary system may include a communication interface configured to receiving a first audio signal acquired from an audio source through a first channel, and a second audio signal acquired from the same audio source through a second channel. The system may also include at least one processor coupled to the communication interface. The at least one processor may be configured to determine channel features based on the first audio signal and the second audio signal individually and determine a cross-channel feature based on the first audio signal and the second audio signal collectively. The at least one processor may further be configured to concatenate the channel features and the cross-channel feature and estimate spectral-spatial masks for the first channel and the second channel using the concatenated channel features and the cross-channel feature. The at least one processor may also be configured to perform beamforming based on the spectral-spatial masks for the first channel and the second channel.