Invention Grant
- Patent Title: Gelling compositions for treating malignant tumours and/or preventing tumour recurrence
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Application No.: US15760249Application Date: 2016-09-16
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Publication No.: US11291630B2Publication Date: 2022-04-05
- Inventor: Nathalie Mignet , Vincent Pierre-Marie Boudy , Johanne Seguin , Daniel Scherman , Yoran Beldengrun
- Applicant: Centre National de la Recherche Scientifique (CNRS) , Université de Paris , Assistance Publique-Hopitaux de Paris , Ecole Nationale Superieure de Chimie de Paris , Institut National de la Sante et de la Recherche Medicale (INSERM)
- Applicant Address: FR Paris; FR Paris; FR Paris; FR Paris; FR Paris
- Assignee: Centre National de la Recherche Scientifique (CNRS),Université de Paris,Assistance Publique-Hopitaux de Paris,Ecole Nationale Superieure de Chimie de Paris,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Centre National de la Recherche Scientifique (CNRS),Université de Paris,Assistance Publique-Hopitaux de Paris,Ecole Nationale Superieure de Chimie de Paris,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris; FR Paris; FR Paris; FR Paris; FR Paris
- Agency: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- Priority: EP15306426 20150916
- International Application: PCT/EP2016/072038 WO 20160916
- International Announcement: WO2017/046369 WO 20170323
- Main IPC: A61K9/06
- IPC: A61K9/06 ; A61K31/282 ; A61K31/513 ; A61K47/34 ; A61K47/36 ; A61K47/02 ; A61N5/10 ; A61P35/00 ; A61K47/10 ; A61K9/00 ; A61K31/555 ; A61K31/519 ; A61K31/37 ; A61K33/243
Abstract:
The present invention relates to gelling compositions, which changes from liquid state to gel state in function of temperature comprising: at least a poloxamer or mixture of poloxamers; at least a gelling agent; and at least an anticancer agent. Said compositions are advantageously used for local administration of an anticancer agent. Said compositions are useful for size-reduction of a tumour before surgical removal of said tumour, for preventing tumour recurrence after surgical removal of a tumour, and/or treating small tumours. They are therefore useful for the treatment of cancer, preferably a cancer of a wall of the digestive system or a gynaecologic cancer. The present invention also relates to a method for preparing said gelling compositions.
Public/Granted literature
- US20190192430A1 GELLING COMPOSITIONS FOR TREATING MALIGNANT TUMOURS AND/OR PREVENTING TUMOUR RECURRENCE Public/Granted day:2019-06-27
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