A ceiling-mounted decontamination unit with one or more internal decontamination sources, which may be UV-C emitters, inside a housing with a hingable panel for access to the internal space of the housing for maintenance and repairs, and one or more fans inside the housing that re-circulate the air in a room and subject the air to the germicidal internal decontamination source inside the housing, decontaminating the air passing through the ceiling-mounted decontamination unit's internal space and destroying viruses, bacteria, and other pathogens. The ceiling-mounted decontamination unit draws the air in from the room or area where the ceiling-mounted unit is installed, subjects the air to the internal decontamination source destroying pathogens, and returns the decontaminated air back to the same room or area from which the air is drawn. An optional luminaire or external decontamination source may be attached to the room- or area-facing exterior of the ceiling-mounted decontamination unit.