Methods for making a microstructured tool having interspersed topographies are disclosed, and the production of articles therefrom. The article has a major surface including first microstructural features and second microstructural features arranged in a pattern visible at least when viewed normal to the first major surface. The first and second microstructural features are different relative to each other, and are selected from the group consisting of cones, diffraction gratings, lenticulars, segments of a sphere, pyramids, cylinders, fresnels, and prisms.