A synchronized transmission (1) used in a motorcycle, wherein a crankshaft actuated by the engine and a driven shaft, connected to a rear wheel, are substantially parallel and kinematically connected therebetween, comprising a first axial actuation synchronizer (16) placed at the front of the crankshaft (2) and a second axial actuation synchronizer (17) arranged at the front of a driven shaft kinematically connected to a rear wheel, each synchronizer (16, 17) comprising a respective rotating cam actuator (26, 29) having a cam (29) apt to be rotated by a respective cam spindle (30) by determining a translation thereof which interferes with an actuation end of the respective synchronizer (16, 17).