The present disclosure provides automatic cleaning system and method. The automatic cleaning system includes a control unit, a Micro Control Unit (MCU), a cleaning device and a sensor device. The control unit is configured to determine a cleaning type for cleaning a protective cover of a camera based on an image captured by the camera and the measured temperature and humidity on the outer surface of the protective cover. The control unit is also configured to generate a cleaning instruction based on the cleaning type. The control unit is also configured to send the instruction to the MCU. The MCU is configured to control the cleaning device to clean the protective cover of the camera in accordance with the cleaning instruction in response to receiving the instruction sent from the control unit.