Invention Grant
- Patent Title: Nitrogen-containing benzoheterocycle compound comprising carboxylic acid group, preparation method and use thereof
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Application No.: US16959691Application Date: 2019-01-18
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Publication No.: US11292785B2Publication Date: 2022-04-05
- Inventor: Shuai Song , Qiang Tian , Yongyong Wu , Mingliang Zhao , Chaolei Wang , Jiaqiang Cai , Lichun Wang , Jingyi Wang
- Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
- Applicant Address: CN Sichuan
- Assignee: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
- Current Assignee: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
- Current Assignee Address: CN Sichuan
- Agency: Honigman LLP
- Agent Thomas A. Wootton, Esq.; Jonathan P. O'Brien
- Priority: CN201810104806.3 20180202
- International Application: PCT/CN2019/072278 WO 20190118
- International Announcement: WO2019/149089 WO 20190808
- Main IPC: C07D403/12
- IPC: C07D403/12 ; A61P1/16
Abstract:
Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like.
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