Invention Grant
![Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors](/docs/US/2022-04-05/US11292802B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors
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Application No.: US16761286Application Date: 2018-11-05
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Publication No.: US11292802B2Publication Date: 2022-04-05
- Inventor: Guohua Zhao , James Mignone
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2018/059157 WO 20181105
- International Announcement: WO2019/094319 WO 20190516
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D487/04 ; C07D519/00
![Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors](/abs-image/US/2022/04/05/US11292802B2/abs.jpg.150x150.jpg)
Abstract:
The disclosure relates to compounds of formula I: Formula I which inhibit αV-containing integrins, and includes pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αV-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders.
Public/Granted literature
- US20210163501A1 PYRROLOPYRAZINE DERIVATIVES AS ALPHA V INTEGRIN INHIBITORS Public/Granted day:2021-06-03
Information query
IPC分类:
