Fiber optic networks having cable assemblies with a predetermined cable-to-connector orientation that cooperate with a multiport so that the cables of the cable assemblies may be routed to the multiport and organized in an efficient and compact manner. In one embodiment, the cable assembly has a fiber optic connector terminated to a cable with a cross-section so that a major axis of the cable cross-section is aligned with a keying portion and locking feature of fiber optic connector. The cable-to-connector orientation allows cable assemblies to be optically connected to the multiport so that the cables may be routed away from the multiport along the connection plane of the multiport in the fiber optic network.