Systems and methods for determining routes to destinations for a vehicle may: generate output signals; obtain road information for a set of roads; determine presence information that indicates whether one or more passengers are present in the vehicle; determine the location information of the vehicle; obtain a target destination that represents a location the vehicle is intended to reach; determine a first route including a first subset of the set of roads; determine a second route including a second subset of the set of roads; and control the vehicle autonomously to traverse the vehicle along either the first route or the second route in accordance with whether one or more passengers are present in the vehicle.