An information handling system may include a bus initiator, a plurality of bus endpoints, and a bus communicatively coupled between the bus initiator and the plurality of bus endpoints, wherein the bus comprises a multiplexer topology of a plurality of multiplexers. The bus initiator may be configured to perform in-band addressing to select a communications channel through the multiplexer topology via an addressing protocol that uses pulse bursts for initiation of the addressing, identification of the communications channel, and termination of the addressing. Pulses of the pulse bursts may be sufficiently short in duration to pass through filters of the bus endpoints such that the pulse bursts are not processed by the endpoints.