Disclosed herein are systems and methods for using machine learning for image-based spoof detection. One embodiment takes the form of a method that includes obtaining an input-data set that includes a plurality of images captured of a biometric-authentication subject by a plurality of cameras of a camera system. The method also includes inputting the input-data set into a trained machine-learning module, and processing the input-data set using the machine-learning module to obtain, from the machine-learning module, a spoof-detection result for the biometric-authentication subject. The method also includes outputting the spoof-detection result for the biometric-authentication subject.