Systems, methods, and computer-readable media are disclosed for planning and scheduling of manufacturing using a receding horizon planning approach that enables the manufacture of multiple products in a flexible and efficient manner. A receding horizon planning engine is provided that receives input data indicative of various manufacturing parameters associated with the manufacture of various products and utilizes the input data to solve an optimization problem with respect to a cost function to generate a receding horizon execution plan indicative of a set of planned manufacturing steps to be executed. Some subset of the planned manufacturing steps (which may include all planned steps) may then be executed. Upon completion of execution of the subset of planned manufacturing steps or upon the occurrence of a trigger event, the optimization problem may be re-solved to obtain a new receding horizon execution plan for a subsequent set of planned manufacturing steps.