A cold chain system with thermosensitive labels linked to an online traceability portal is disclosed. The system includes a plurality of human a machine readable code labels having irreversible thermosensitive inks placed on various products. The labels optionally having multiple codes paired with various predefined discrete images or strings detected using optical methods or text-based transmission and communication protocols. The system can enhance cold chain quality and security by allowing real time validation and traceability from factory to end users through an online platform compatible with mobile devices. The system can also enhance both manual and technological cold chain security methods for countries that have varying degrees of technological capability to ultimately improve vulnerable supply chains.