A computer-based method for generating a custom hand brace for a patient includes compiling optical data captured during a three-dimensional scan of a target hand of the patient into a three-dimensional hand model of the target hand; and receiving a diagnosis for an injury to the target hand of the patient. Based on the diagnosis, the method includes generating a custom hand brace model by extracting a first set of points from the three-dimensional hand model to generate an initial hand brace model; forming an interior surface of the initial hand brace model based on the first set of points; deforming the interior surface of the initial hand brace model into alignment with an exterior surface of the three-dimensional hand model to generate the custom hand brace model; and queuing the custom hand brace model for fabricating at an advanced manufacturing system.