A pixel driving method is provided. The method includes: acquiring pixel signals of sub-pixels of each color of each unit pixel in a pixel block, where the unit pixel includes a red sub-pixel, a green sub-pixel and a blue sub-pixel; and loading first-type gray-scale signals to a part of same-color sub-pixels in the pixel block and loading second-type gray-scale signals that are not equal to the first-type gray-scale signals to the remaining same-color sub-pixels based on a preset rule according to the pixel signals of the sub-pixels of each color, signal determination intervals and a proportion standard value corresponding to each of the signal determination intervals, thus improving the graininess of the pixel block during display.