Techniques are disclosed herein for using standardized meals and digital devices can be utilized outside a clinical setting to assist in determining/predicting one or more clinical states associated with one or more individuals. Using the technologies described herein, different techniques can be utilized to for using nutritional response measurements. For example, response measurements can be obtained for two fat meals instead of a single fat meal. Data associated with a circadian rhythm (e.g., sleep times, awake times) can also be utilized to improve the accuracy of the measured biomarkers. In other examples, biome data and other data can be utilized.