Device and method are disclosed for downlink gain compensation at a radio unit. According to an embodiment, the device comprises a pre-distortion circuit, a digital gain adjuster, a gain determiner and a first gain controller. The pre-distortion circuit is configured to generate and apply a pre-distortion to an input signal. The digital gain adjuster is configured to apply an adjustable gain to an output signal from the pre-distortion circuit. The gain determiner is configured to determine a gain difference between a target downlink gain and current downlink gain. The first gain controller is configured to control the digital gain adjuster based on the gain difference. A radio unit comprising the device is also disclosed.