An endoscope distal end structure includes: an imaging module configured to generate an image signal and transmit the generated image signal using a cable; a frame having a through hole, the frame being configured to hold the imaging module with the imaging module being inserted into the through hole from an insertion port; a first adhesive that is arranged in a gap between an outer circumference of a proximal end part of a resin seal and an inner circumferential surface of the frame on a side of the insertion port; and a second adhesive that is arranged in a gap between the inner circumferential surface of the frame at a position in which the through hole is formed and the imaging module that is inserted into the through hole.