Embodiments of interference coordination for aerial vehicle user equipment (UE) are described. In some embodiments, a base station (BS) is configured to select a subset of time-frequency resources dedicated for use in serving aerial vehicle UEs and communicate with the aerial vehicle UEs via the subset of time-frequency resources. In some embodiments, the BS may transmit signaling to a neighbor BS that indicates the BS has dedicated the subset of time-frequency resources for serving aerial vehicle UEs and the subset of time-frequency resources to be used. The BS may receive an indication from the neighbor BS that a neighbor BS is to dedicate the subset of time-frequency resources to serve aerial vehicle UE, and based on the indication, the BS may reduce transmission activities in the subset of time-frequency resources, including refraining from transmitting or reducing an amount of information or power level of signaling to the aerial vehicle UEs.