Wearable sensors that measure one or more parameters such as pressure, force, acceleration, or skin temperature, are used to measure, record, display and monitor the efficacy of therapeutic maneuvers applied to a subject by an operator. Systems and methods for assessing the physiological efficacy of therapeutic maneuvers performed by an operator on a subject in need thereof, and provide a way to guide subsequent therapeutic maneuvers toward optimal outcome. In some embodiments, the systems and methods measure, record, and display physiological parameters of an operator and/or subject during application of cardiopulmonary resuscitation (CPR).