A surgical site infection management lighting system that is effective and safe for human use to reduce or eliminate surgical site infections. The system provides multiple focused electromagnetic radiation frequencies at minimal energy levels for surgical and medical procedures that kills pathogens with electromagnetic radiation sources. The system includes an aiming laser, a distance sensor, a camera for providing images of the surgical site, and a motion sensor for providing control parameters. Fused silica lenses are utilized to focus the visible light for high illumination and selected electromagnetic radiation frequencies at minimal energy levels that are lethal to pathogens. The lighting system can be associated with an articulable arm, a mobile base stand, a handheld unit or a head-mounted unit.