Invention Grant
- Patent Title: Antagonists of the muscarinic acetylcholine receptor M4
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Application No.: US16757245Application Date: 2018-10-20
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Publication No.: US11299481B2Publication Date: 2022-04-12
- Inventor: Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Julie L. Engers , Kayla J. Temple , Aaron M. Bender , Logan A. Baker
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2018/056803 WO 20181020
- International Announcement: WO2019/079783 WO 20190425
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D209/52 ; C07D401/14 ; C07D403/12 ; C07D405/14 ; C07D413/14 ; C07D417/12 ; C07D471/04 ; C07D493/08
Abstract:
Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
Public/Granted literature
- US20210188820A1 ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 Public/Granted day:2021-06-24
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