Invention Grant
- Patent Title: Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
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Application No.: US16629773Application Date: 2018-07-11
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Publication No.: US11299488B2Publication Date: 2022-04-12
- Inventor: Donald J. P. Pinto , Tarun Kumar Maishal
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2018/041562 WO 20180711
- International Announcement: WO2019/014303 WO 20190117
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D401/12 ; C07D401/14 ; C07D413/12 ; C07D417/12

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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