Invention Grant
- Patent Title: Method of producing proteins in filamentous fungi with decreased CLR2 activity
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Application No.: US15779595Application Date: 2016-12-02
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Publication No.: US11299522B2Publication Date: 2022-04-12
- Inventor: Stefan Haefner , Andreas Thywissen , Holger Hartmann , Nico Boehmer
- Applicant: BASF SE
- Applicant Address: DE Ludwigshafen am Rhein
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen am Rhein
- Agency: Armstrong Teasdale LLP
- Priority: EP15197497 20151202
- International Application: PCT/EP2016/079526 WO 20161202
- International Announcement: WO2017/093450 WO 20170608
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N9/14 ; C12N1/15 ; C07K14/37 ; C12N9/16 ; C12N9/24 ; C12N15/80
Abstract:
The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
Public/Granted literature
- US20200308235A1 METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLR2 ACTIVITY Public/Granted day:2020-10-01
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