Invention Grant
- Patent Title: Gene combination capable of high-efficiency expression of recombinant human nerve growth factor
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Application No.: US16954354Application Date: 2018-11-08
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Publication No.: US11299548B2Publication Date: 2022-04-12
- Inventor: Hai Chen , Hongliang Sun , Yi Zhang , Yuesheng Wang
- Applicant: Xintrum Pharmaceuticals, Ltd.
- Applicant Address: CN Jiangsu
- Assignee: Xintrum Pharmaceuticals, Ltd.
- Current Assignee: Xintrum Pharmaceuticals, Ltd.
- Current Assignee Address: CN Jiangsu
- Agency: Liu Chen & Hoffman LLP
- Agent Yong Chen; Lin Sun-Hoffman
- Priority: CN201810252273.3 20180326
- International Application: PCT/CN2018/114594 WO 20181108
- International Announcement: WO2019/184372 WO 20191003
- Main IPC: C12N15/18
- IPC: C12N15/18 ; C07K16/28 ; A61K38/18
Abstract:
A gene combination capable of high-efficiency expression of rhNGF is provided to optimize gene expression regulation components of a recombinant human nerve growth factor. The gene combination enhances expression of rhNGF. As shown by experiments, the gene combination is capable of high-efficiency expression of a recombinant human nerve growth factor (rhNGF) with natural activity in a eukaryotic expression system.
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