Invention Grant
- Patent Title: Enhanced DNA sensing via catalytic aggregation of gold nanoparticles by DNA hybridization chain reaction
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Application No.: US15877128Application Date: 2018-01-22
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Publication No.: US11299771B2Publication Date: 2022-04-12
- Inventor: Jeunghoon Lee , Bernard Yurke , Elton Graugnard , Will Hughes , Bert Huttanus
- Applicant: Jeunghoon Lee , Bernard Yurke , Elton Graugnard , Will Hughes , Bert Huttanus
- Applicant Address: US ID Boise; US ID Boise; US ID Boise; US ID Blacksburg; US VA Blacksburg
- Assignee: Jeunghoon Lee,Bernard Yurke,Elton Graugnard,Will Hughes,Bert Huttanus
- Current Assignee: Jeunghoon Lee,Bernard Yurke,Elton Graugnard,Will Hughes,Bert Huttanus
- Current Assignee Address: US ID Boise; US ID Boise; US ID Boise; US ID Blacksburg; US VA Blacksburg
- Agency: McKee, Voorhees & Sease, PLC
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/682
Abstract:
The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes.
Public/Granted literature
- US20180216158A1 ENHANCED DNA SENSING VIA CATALYTIC AGGREGATION OF GOLD NANOPARTICLES BY DNA HYBRIDIZATION CHAIN REACTION Public/Granted day:2018-08-02
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