Invention Grant
- Patent Title: Method for the quantification of Faecalibacterium prausnitzii phylogroup I and/or phylogroup II members and the use thereof as biomarkers
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Application No.: US15751805Application Date: 2016-08-11
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Publication No.: US11299788B2Publication Date: 2022-04-12
- Inventor: Mireia Lopez Siles , Librado Jesus Garcia Gil , Xavier Aldeguer Mante , Margarita Martinez Medina
- Applicant: Universitat de Girona , Fundado Institut D'Investigacio Biomedica de Girona Dr. Josep Trueta , Goodgut S.L.
- Applicant Address: ES Girona; ES Salt; ES Girona
- Assignee: Universitat de Girona,Fundado Institut D'Investigacio Biomedica de Girona Dr. Josep Trueta,Goodgut S.L.
- Current Assignee: Universitat de Girona,Fundado Institut D'Investigacio Biomedica de Girona Dr. Josep Trueta,Goodgut S.L.
- Current Assignee Address: ES Girona; ES Salt; ES Girona
- Agency: Seed IP Law Group LLP
- Priority: EP15382427 20150811
- International Application: PCT/EP2016/069188 WO 20160811
- International Announcement: WO2017/025617 WO 20170216
- Main IPC: C12Q1/689
- IPC: C12Q1/689 ; C12Q1/6883 ; C12Q1/6886
Abstract:
The present invention relates to a novel method for an accurate quantification in intestinal samples of Faecalibacterium prausnitzii phylogroup I members (PHGI) and/or Faecalibacterium prausnitzii phylogroup II members (PHGII). It further relates to a method for detecting intestinal diseases, including the screening, diagnosis, differential diagnosis, and/or monitoring of disease activity or progression in a human subject comprising determining the abundance of PHGI and/or PHGII in an intestinal sample from said subject. Moreover, it relates to a method for the prediction of the efficacy of a drug in the therapeutic treatment of an intestinal disease in a human subject comprising determining the abundance of PHGI and/or PHGII in an intestinal sample from said subject.
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