A temperature compensation circuit for a power amplifier is provided, wherein data of circuit configurations corresponding to specific temperatures (including data associated with an output terminal voltage, a bias voltage, an adaptive bias, and a matching impedance of the power amplifier) for the power amplifier is stored in a read-only memory. Therefore, the temperature compensation circuit is capable of reading the data according to a temperature sensing signal to adjust the circuit configuration of the power amplifier accordingly, thereby, in a case of a constant input power of the power amplifier, an output power variance of the power amplifier is within a second interval (e.g., −10%˜+10%) when an environment temperature varies within a first interval. Therefore, the power amplifier has a stable gain.