Methods and systems for network-based messaging systems with database management for supporting based inter-user communications, such as via computing devices, are disclosed. The methods and systems facilitate improved message transmission management for more efficient communications. The methods and systems can provide enhanced electronic communications, such as via electronic mail or text messaging. Improved communication tools are provided to better manage and/or control communications. The computing devices can be personal communication/computing devices, such as mobile, portable or handheld computing devices (e.g., smart phone, a laptop, a tablet, etc.).