An Internet of Things sanitization system and method of operation through a blockchain network provides one or more independently operating sanitizing assemblies comprise a reservoir containing sanitizing medium and a sanitizing mechanism work to sanitize/clean a surface. The sanitizing assemblies connect through a blockchain network, so as to generate, collect, process, and communicate data pertinent to the cleaning. The data is transmitted across a peer-to-peer network, such as a blockchain network for the purposes of: identifying a user; determining which of the sanitizing assemblies and components thereof are operable, and determining usage metrics of the sanitization assemblies. Data is collected directly from the sanitizing assemblies through various user input interfaces. An Internet of Things motherboard operational in the sanitizing assemblies to enable communication between sanitizing assemblies, network nodes, and a centralized server. A network controller and a network interface enhance operation and communications for the sanitizing assemblies.