Certain features relate to systems and methods for optimizing the radio frequency characteristics of signals transmitted between a radio base station (RBS) and a distributed antenna system (DAS). A self-optimizing network (SON) entity can determine adjustments to radio frequency operations and management parameters at the RBS based on radio frequency parameters measured by a measurement and configuration module at the DAS. Adjustments to radio frequency operations and management parameters can include adjustments configured to compensate for signal latency caused by the DAS. Adjustments to radio frequency operations and management parameters can also include adjustments to signal gain due to noise rise caused by the DAS. The SON entity can also measure nominal receive power levels for the RBS for purposes of open loop power control.