The five-axis angular adjustment and azimuth rotation mechanism relates to the field of products for vehicle-mounted display screens and in particular relates to a five-axis angular adjustment and azimuth rotation mechanism, including a display screen assembly, wherein a turning mechanism assembly is connected to one side of the display screen assembly via bolts, a panel assembly is arranged on one side of the turning mechanism assembly via bolts, and a main machine assembly is arranged on one side of the panel assembly via bolts, and the display screen assembly includes a first linear sliding mechanism, a first axial rotation mechanism, a second axial rotation mechanism and a third axial rotation mechanism, the first linear sliding mechanism includes two screen bars arranged on one side of the display screen assembly via bolts. The disclosure is suitable for different vehicle types.