Invention Grant
- Patent Title: N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
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Application No.: US17093506Application Date: 2020-11-09
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Publication No.: US11306056B2Publication Date: 2022-04-19
- Inventor: John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- Applicant: Cardioxyl Pharmaceuticals, Inc. , The Johns Hopkins University
- Applicant Address: US NC Chapel Hill; US MD Baltimore
- Assignee: Cardioxyl Pharmaceuticals, Inc.,The Johns Hopkins University
- Current Assignee: Cardioxyl Pharmaceuticals, Inc.,The Johns Hopkins University
- Current Assignee Address: US NC Chapel Hill; US MD Baltimore
- Agency: Byrne Poh LLP
- Agent Nina R. Horan
- Main IPC: C07C311/00
- IPC: C07C311/00 ; C07C317/00 ; C07C323/00 ; C07D231/00 ; C07C311/48 ; C07C317/14 ; C07C323/67 ; C07D213/74 ; C07D261/10 ; C07D263/58 ; C07D285/125 ; C07D295/096 ; C07D307/82 ; C07D333/62 ; C07D309/12 ; C07D317/14 ; C07D231/18 ; C07D333/34
Abstract:
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
Public/Granted literature
- US20210053915A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS Public/Granted day:2021-02-25
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