Invention Grant
- Patent Title: Chemical and method for analyzing DNA sequence by visualizing single-molecule DNA and use thereof
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Application No.: US16446887Application Date: 2019-06-20
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Publication No.: US11306074B2Publication Date: 2022-04-19
- Inventor: Kyu Bong Jo , Seong Hyun Lee , Hiroshi Sugiyama
- Applicant: SOGANG UNIVERSITY RESEARCH FOUNDATION
- Applicant Address: KR Seoul
- Assignee: SOGANG UNIVERSITY RESEARCH FOUNDATION
- Current Assignee: SOGANG UNIVERSITY RESEARCH FOUNDATION
- Current Assignee Address: KR Seoul
- Agency: Clark & Elbing LLP
- Agent Susan M. Michaud
- Priority: KR10-2018-0086255 20180724
- Main IPC: C07D405/14
- IPC: C07D405/14 ; C12Q1/68 ; C12Q1/6806
Abstract:
The present disclosure relates to a composition for analysis of DNA sequences and a method for analysis of DNA sequences by using the same and, more particularly, to a composition comprising the compound represented by Chemical Formula 1 and a method for analysis of DNA sequences, the method comprising a step of treating a sample with the same. The compound represented by Chemical Formula 1 in which TAMRA is linked to polypyrrole specifically binds an A/T base pair (W) to fluoresce alone without causing DNA photocleavage. Therefore, the compound is useful for DNA analysis particularly at the single DNA molecule level.
Public/Granted literature
- US20200031810A1 CHEMICAL AND METHOD FOR ANALYZING DNA SEQUENCE BY VISUALIZING SINGLE-MOLECULE DNA AND USE THEREOF Public/Granted day:2020-01-30
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