Invention Grant
- Patent Title: Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
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Application No.: US16471424Application Date: 2017-12-18
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Publication No.: US11306075B2Publication Date: 2022-04-19
- Inventor: Eliot J. Davidowitz , James G. Moe , Allen B. Reitz , Haiyan Bian , Charles Gluchowski , James Hendrix , Albert S. Yehaskel , Mark E. McDonnell , H. Marie Loughran
- Applicant: OLIGOMERIX INC.
- Applicant Address: US NY Bronx
- Assignee: OLIGOMERIX INC.
- Current Assignee: OLIGOMERIX INC.
- Current Assignee Address: US NY Bronx
- Agency: Sorell, Lenna & Schmidt LLP
- Agent William D. Schmidt, Esq.
- International Application: PCT/US2017/067032 WO 20171218
- International Announcement: WO2018/118782 WO 20180628
- Main IPC: C07D409/14
- IPC: C07D409/14 ; C07D307/80 ; C07D405/14
Abstract:
Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.
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