Invention Grant
- Patent Title: Phenylacetamides as inhibitors of rock
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Application No.: US16629736Application Date: 2018-07-11
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Publication No.: US11306081B2Publication Date: 2022-04-19
- Inventor: Michael J. Orwat , Donald J. P. Pinto
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2018/041559 WO 20180711
- International Announcement: WO2019/014300 WO 20190117
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D401/12 ; C07D405/14 ; C07D413/12 ; C07D417/12 ; C07D471/04 ; C07D513/04 ; C07F9/6558 ; C07F9/6561

Abstract:
The present invention provides compounds of Formula (I): Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20210147407A1 PHENYLACETAMIDES AS INHIBITORS OF ROCK Public/Granted day:2021-05-20
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