Invention Grant
- Patent Title: Spirooxindole compounds as GSK3B inhibitors and process for preparation thereof
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Application No.: US16492359Application Date: 2018-03-09
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Publication No.: US11306100B2Publication Date: 2022-04-19
- Inventor: Prathama S. Mainkar , Mohammad Abdul Sattar , Pitchakuntla Mallesham , Togapur Pavan Kumar , Divya Duscharla , Ummanni Ramesh , Srivari Chandrasekhar
- Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Applicant Address: IN New Delhi
- Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee Address: IN New Delhi
- Agency: Abelman, Frayne & Schwab
- Agent Stefan Knirr
- Priority: IN201611008487 20170310
- International Application: PCT/IN2018/050134 WO 20180309
- International Announcement: WO2018/163216 WO 20180913
- Main IPC: C07D491/107
- IPC: C07D491/107 ; A61P35/00

Abstract:
The present invention provides a compound of general formulae I useful as GSK3β inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.
Public/Granted literature
- US20210284650A1 SPIROOXINDOLE COMPOUNDS AS GSK3B INHIBITORS AND PROCESS FOR PREPARATION THEREOF Public/Granted day:2021-09-16
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